Guesthouse holiday rentals in Nassau County

Find and book unique guesthouse rentals on Airbnb

Top-rated Guesthouses in Nassau County

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Guest favourite

Guesthouse in Jacksonville

4.91 out of 5 average rating, 128 reviews

{Owl's Nest} Avondale Guesthouse *No Cleaning Fee!

Get cozy in this Historic Avondale guesthouse with it's modern, boho accents. Cottage boasts a bright living area & work space, a place for mixing cocktails, & a private front porch perfect for reading a book or soaking up the sunshine. Take a cruise on our bikes through Avondale or down to the river to enjoy a Florida sunset. Located just minutes from Downtown Jax & Sports Complexes, Naval Air Station, Area hospitals, Florida State College @ Jax, Area Beaches, St. John's River, I-95 & I-10.

Guest favourite

Guesthouse in St. Marys

4.93 out of 5 average rating, 143 reviews

Next - ta - Sea

This is a detached two bedroom chalet. The inside has been newly renovated and we are constantly touching up! The St Marys’ ferry to Cumberland Island is a few blocks away! The host will help make the most of your trip by providing beach chairs, coolers, umbrellas, wagons and tips for a great day at the beach. Jacksonville, Amelia Island, Fernandina, Jekyll and St Simmons Island are all within 30 min. Go enjoy the day there, then relax with marsh views next to the sea ~ it’s pure Next-ta-Sea

Guest favourite

Guesthouse in Jacksonville

4.74 out of 5 average rating, 442 reviews

Pool House-2 Bdr/1Ba Apt-Pool-Sleeps 5-Pets OK

NO EVENTS OR PARTIES Entire Apartment-Completely Private-Sleeps 5 Pool-Balcony Completely Remodeled 2022. Private Drive/Parking, Overlooks Pool. Peace & Quiet-1.2 Acres-Center of Jacksonville. Ideal for Business/Tourist. Short Distance to Everything Jacksonville. *15 min. from Beaches, *Downtown, Mayo Clinic, *Cruise Ships, I-95 & I-295. * Duval County Taxes Included in Listing Price *FL registered business * Pet Friendly-Fee:$77 per stay *Washer/Dryer Behind Apartment * 2nd Floor-12 Steps

Guest favourite

Guesthouse in Jacksonville

4.98 out of 5 average rating, 129 reviews

Casa Azul: The Tree House with Bath House

A peaceful, unique treehouse in historic Riverside. This charming treehouse is a small bedroom space built up high with a wrap-around deck and adjacent spacious private bathhouse. The bedroom is perfect for one person with twin stacked beds -can be unstacked to accommodate two for sleeping. There is a treehouse library, The outdoor kitchenette underneath has sink, dishes, stovetop, table, small fridge, espresso maker & coffee. Private guest entrance & driveway. Perfect for a creative soul.

Guest favourite

Guesthouse in Jacksonville

4.99 out of 5 average rating, 226 reviews

Luxury Avondale Guest House, Walk to Shops

Featured in the Jacksonville Home Magazine! The Luxury Avondale Guest House is in the exquisite historic neighborhood of Avondale. Ten minutes from downtown sports & entertainment complexes, and several major health care facilities, St. Vincent's Hospital, Baptist Medical Center and the world renowned MD Anderson Cancer Center. Three short blocks to “The Shoppes of Avondale,” with an outstanding array of restaurants and venues to enjoy a streetside café-style meal, cocktail and desserts.

Guest favourite

Guesthouse in Jacksonville

4.95 out of 5 average rating, 436 reviews

Jax Backyard Bungalow

Rent this pet friendly guest house in our quiet well-groomed backyard. Studio comes with queen-size bed, couch, closet, mini fridge, Keurig, microwave, table & chairs. Enjoy DirecTV & dedicated WiFi router. Savor a peaceful cup of coffee or evening cocktail on the attached wood deck. Well behaved pets are encouraged to run free in the fully fenced in yard. Our black lab would love the company! Get to TIAA Bank Field in less than 5 mins or the beach in about 25 mins. Must be 25 to book

Superhost

Guesthouse in Fernandina Beach

4.79 out of 5 average rating, 154 reviews

Beautiful farmhouse in Fernandina Beach

Come and soak in a few nights or even a few weeks of R&R in beautiful Fernandina Beach! Located about 10 minutes from the gorgeous Atlantic ocean, historic downtown Fernandina, and all the amazing shopping, restaurants, and outdoor adventures your heart could desire, your only care will be what fun options to enjoy first. We are located just a half-hour away from the airport or lovely Saint Mary's, where you can catch a ferry to Cumberland Island and enjoy a picnic lunch on the beach.

Guest favourite

Guesthouse in Jacksonville Beach

4.99 out of 5 average rating, 184 reviews

Tropical guest house a few blocks from the beach

Take it easy at this unique and tranquil getaway. Private modern quest house located on lush tropical grounds behind main house. Includes: loft bedroom, full bath, kitchenette, wifi, air conditioning, private patio, and outdoor shower. Property is gated with parking. Walking distance to beach, bars, shops and restaurants. Hammock, volley ball, firepit, BBQ and bikes available upon request. Pets welcome. Fishing pier, boating, kayaking and golf options within a short distance.

Guest favourite

Guesthouse in Jacksonville

4.95 out of 5 average rating, 626 reviews

The Captain's Quarters o|--)

This two story loft garage is detached and is set in the back of the property 45 feet from the main house. The first floor has the kitchen and living space, then walk up the spiral staircase to the bedroom with cathedral ceiling with track lights and ensuite bathroom. I love dogs and allow them with permission first. No pets without prior approval (pet fee is min $50 per stay or $10 per day which ever is greater) My location is a short walk to Starbucks and other restaurants.

Guest favourite

Guesthouse in Jacksonville

4.97 out of 5 average rating, 143 reviews

Santorini A Mediterranean Studio Escape…Riverside

Escape to a tranquil Greek villa in the heart of Riverside, Jacksonville. Inspired by the cliff top town of Ioa on the island of Santorini, you will experience the allure of the Aegean Islands as you step into this whitewashed windswept studio. Immerse yourself in bleached white rock, stucco, and cobalt blue accents. Escape if you’d like or walk to local eateries and entertainment. Regardless, enjoy the magic of a Grecian villa hidden in the middle of Riverside Jacksonville!

Guest favourite

Guesthouse in Jacksonville

5 out of 5 average rating, 116 reviews

Cozy Cottage in Springfield, Downtown Jax

🤍 We can't wait to host you! The Cottage on 4th is located in the eclectic Historic Springfield neighborhood in Jacksonville's urban core. Situated in close proximity to awesome restaurants, coffee shops, breweries, and entertainment venues. Located 1.5 miles or less from TIAA Bank Field, Daily’s Place, Vystar Veterans Memorial Arena, and 121 Financial Ballpark (Jacksonville Jumbo Shrimp stadium). 13 miles from JAX airport and 16 miles from the beach.

Guest favourite

Guesthouse in St. Marys

4.98 out of 5 average rating, 197 reviews

Beautiful detached apt. in Downtown St. Marys, GA

Retreat to southern coastal Georgia in this beautiful and clean vacation rental close to downtown St. Marys. A few blocks from the ferry to visit Cumberland Island National Seashore. Enjoy easy access to downtown restaurants, shops and the St. Mary's waterfront area. This detached studio apartment shares a driveway with the owners' residential home, but you'll have privacy with a separate entrance and an enclosed yard with chairs and a firepit.