Guesthouse holiday rentals in South Carolina
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Top-rated Guesthouses in South Carolina
Guests agree: These guesthouses are highly rated for location, cleanliness and more.
Holiday rentals for every style
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Popular amenities for South Carolina guesthouses
Family-Friendly guesthouses
Guesthouse in North Charleston
5.0 out of 5 average rating, 112 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 220 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Guesthouse in Townville
4.87 out of 5 average rating, 78 reviewsLisa’s Lodge
Guesthouse in Camden
4.94 out of 5 average rating, 179 reviewsRed Roof Loft @ FireFly Farm
Guesthouse in Ridgeville
4.82 out of 5 average rating, 213 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Summerville
4.98 out of 5 average rating, 645 reviews★Delightful guest house near historic plantations★
Guesthouse in Beaufort
4.98 out of 5 average rating, 360 reviewsThe Wren Guest House
Guesthouse in Salem
4.88 out of 5 average rating, 290 reviewsMountain Edge Loft
Guesthouses with a patio
Guesthouse in Abbeville
4.95 out of 5 average rating, 108 reviews1-bedroom guesthouse in Abbeville, SC
Guesthouse in Charleston
4.93 out of 5 average rating, 172 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Guesthouse in Johns Island
4.91 out of 5 average rating, 108 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Columbia
4.95 out of 5 average rating, 148 reviewsRenovated One Bedroom Guest House by UofSC
Guesthouse in Charleston
4.97 out of 5 average rating, 128 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Spartanburg
5.0 out of 5 average rating, 39 reviewsThe Lodge at Pythian Park
Guesthouse in Campobello
4.96 out of 5 average rating, 72 reviewsBungalow on a 3 acre mini farm
Guest house rentals with a washing machine and dryer
Guesthouse in Florence
4.92 out of 5 average rating, 131 reviewsMidtown Retreat - Guest House in heart of Florence
Guesthouse in Florence
4.99 out of 5 average rating, 668 reviewsBoho Private Downtown Stay Near I-95 & Hospital
Guesthouse in Saint Helena Island
4.99 out of 5 average rating, 189 reviewsCharming Waterfront Cottage with Beautiful Views.
Guesthouse in Summerville
4.97 out of 5 average rating, 218 reviewsTiny Oak Cottage in Historic Downtown Summerville
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 409 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Guesthouse in Lyman
4.99 out of 5 average rating, 124 reviewsBlue Heron Hideaway Lakeside Retreat
Guesthouse in Columbia
4.98 out of 5 average rating, 130 reviews❃ The Rosewood Loft ❃ Desk, Kitchen & Laundry
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