Mansion holiday rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: These mansions are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Luxury mansion rentals
Villa in Panamá
5.0 out of 5 average rating, 32 reviewsBreathtaking Views Mansion w/King Beds
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Home in Panamá
5.0 out of 5 average rating, 9 reviewsUnique 4 room house - direct access to the beach
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Apartment in Panamá
5.0 out of 5 average rating, 21 reviewsTop Floor Condo 6 bedroom with amazing views
Apartment in Maria Chiquita
4.97 out of 5 average rating, 62 reviewsSpacious 4Br Beachside Getaway at Playa Escondida
Apartment in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPenthouse in Playa Escondida 4 bedrooms
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Pet-friendly mansion rentals
Home in Playa Bluff
5.0 out of 5 average rating, 17 reviewsJungle House 100m from the beach
Home in San Carlos
4.93 out of 5 average rating, 88 reviewsBeach House-Ocean View Rooftop Jacuzzi & Pool
Villa in Portobelo
5.0 out of 5 average rating, 43 reviewsEntire Villa with pool in front of beach!
Apartment in San Carlos District
4.99 out of 5 average rating, 79 reviewsAmazing Oceanfront apartment in San Carlos
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Home in San José
5.0 out of 5 average rating, 20 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Costa Esmeralda
4.97 out of 5 average rating, 71 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Mansion rentals with a pool
Villa in Río Hato
5.0 out of 5 average rating, 39 reviewsLuxury 4BR Villa + Guesthouse & Pool @Buenaventura
Condo in Maria Chiquita
5.0 out of 5 average rating, 22 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Apartment in Río Hato
5.0 out of 5 average rating, 18 reviews4 Bedroom Private Pool Paradise in Buenaventura
Apartment in Panama City
4.95 out of 5 average rating, 19 reviews22M Spectacular Penthouse New Design Oceanview
Apartment in María Chiquita
4.94 out of 5 average rating, 67 reviewsPlaya Escondida Resort & Marina
Home in Pedasí
4.83 out of 5 average rating, 6 reviewsOcean View From The Jungle!
Home in Río Hato
4.98 out of 5 average rating, 97 reviewsComplete House for a Perfect Stay
Home in Provincia de Panamá Oeste
4.88 out of 5 average rating, 17 reviewsLuxurious beach front home in Veracruz
Destinations to explore
- Rentals with a fireplace Panama
- Rentals with breakfast Panama
- Kid-friendly rentals Panama
- Rentals with pools Panama
- Rentals with a patio Panama
- Farmstay rentals Panama
- Cottage rentals Panama
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- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Island rentals Panama
- Tree house rentals Panama
- Hotel rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
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- Apartment rentals Panama
- Boutique hotel rentals Panama
- Nature eco lodge rentals Panama
- Holiday home rentals Panama
- Rentals with an accessible height bed Panama
- Monthly Rentals Panama
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- Rentals with a kayak Panama
- Boat rentals Panama
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- Bed and breakfasts Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- House rentals Panama
- Rentals with a home theatre Panama
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- Guesthouse rentals Panama
- Rentals with a washing machine and dryer Panama
- Beach house rentals Panama
- Pet-friendly rentals Panama
- Bungalow rentals Panama
- Townhouse rentals Panama
- Rentals with beach access Panama
- Loft rentals Panama
- Rentals with a sauna Panama
- Rentals with a hot tub Panama
- Wheelchair accessible rentals Panama
- Rentals with lake access Panama
- Villa rentals Panama
- Rentals with a fire pit Panama
- Family-friendly rentals Panama
- Private suite rentals Panama
- Tiny house rentals Panama
- Beach condo rentals Panama
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