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Mansion holiday rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: These mansions are highly rated for location, cleanliness and more.
Holiday rentals for every style
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Popular amenities for Panama mansion rentals
Luxury mansion rentals
![](https://a0.muscache.com/im/pictures/9eae519e-e95f-4114-b64c-49851cb37156.jpg?im_w=720)
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
![](https://a0.muscache.com/im/pictures/miso/Hosting-745919675205709734/original/0634bd11-d34a-401f-848b-d2e742d3481d.jpeg?im_w=720)
Villa in Buenaventura, El Chirú
4.85 out of 5 average rating, 47 reviewsLake House | Pool | King Beds | Next to Beach Club
![](https://a0.muscache.com/im/pictures/miso/Hosting-730334642051722346/original/3af95501-79b9-4a0c-8d1b-483b48180bba.jpeg?im_w=720)
Villa in Panamá
5.0 out of 5 average rating, 34 reviewsBreathtaking Views Mansion w/King Beds
![](https://a0.muscache.com/im/pictures/e5b61c05-bc32-4b29-9eb1-d9e17de0c94c.jpg?im_w=720)
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
![](https://a0.muscache.com/im/pictures/prohost-api/Hosting-33753059/original/7aab71f6-37df-4643-b8ad-173a7fa9b402.jpeg?im_w=720)
Apartment in Panama City
4.68 out of 5 average rating, 250 reviewsPenthouse with rooftop and pool 5 rooms Di5
![](https://a0.muscache.com/im/pictures/miso/Hosting-769016131481959207/original/b37eafdf-2e1e-4ea5-a4bb-cbf7186c16a7.jpeg?im_w=720)
Apartment in Maria Chiquita
4.95 out of 5 average rating, 64 reviewsSpacious 4Br Beachside Getaway at Playa Escondida
![](https://a0.muscache.com/im/pictures/eab69304-067c-40dd-af12-980ff6a07e12.jpg?im_w=720)
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
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Apartment in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPenthouse in Playa Escondida 4 bedrooms
Pet-friendly mansion rentals
![](https://a0.muscache.com/im/pictures/ac46f6de-bbc3-40c0-9504-4beded0d1c8c.jpg?im_w=720)
Apartment in San Carlos District
4.99 out of 5 average rating, 81 reviewsAmazing Oceanfront apartment in San Carlos
![](https://a0.muscache.com/im/pictures/hosting/Hosting-U3RheVN1cHBseUxpc3Rpbmc6NDA2ODI1NTM%3D/original/1bc88917-4919-4552-8831-e4bceb5ffb75.jpeg?im_w=720)
Home in San Carlos
4.93 out of 5 average rating, 89 reviewsBeach House-Ocean View Rooftop Jacuzzi & Pool
![](https://a0.muscache.com/im/pictures/miso/Hosting-994864813340562760/original/07cef3c3-642a-47f6-a2e2-4ad3ab036c68.jpeg?im_w=720)
Home in Playa Bluff
5.0 out of 5 average rating, 18 reviewsJungle House 100m from the beach
![](https://a0.muscache.com/im/pictures/f374b99a-d297-4cac-981d-8ede36624628.jpg?im_w=720)
Villa in Portobelo
5.0 out of 5 average rating, 44 reviewsEntire Villa with pool in front of beach!
![](https://a0.muscache.com/im/pictures/8fa9b36c-3e5b-408a-aed0-ca71e5b1e7c1.jpg?im_w=720)
Condo in San Carlos District
4.97 out of 5 average rating, 38 reviewsPunta Caelo Beach Front View
![](https://a0.muscache.com/im/pictures/2925b05c-51c3-45c0-be1b-51e074c6b820.jpg?im_w=720)
Home in Río Hato
4.98 out of 5 average rating, 99 reviewsRenewed / Make yourself at Home / Enjoy
![](https://a0.muscache.com/im/pictures/284e0802-803e-4ca5-acfe-6b965e923876.jpg?im_w=720)
Villa in Costa Esmeralda
4.97 out of 5 average rating, 71 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
![](https://a0.muscache.com/im/pictures/miso/Hosting-1017985587792513392/original/64eb73f6-57ce-4d6c-83e4-d0f5db56db92.jpeg?im_w=720)
Home in San José
5.0 out of 5 average rating, 21 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Mansion rentals with a pool
![](https://a0.muscache.com/im/pictures/hosting/Hosting-949273102038011650/original/bcf81205-e6fb-4ae1-b918-8d7081b32063.jpeg?im_w=720)
Apartment in Río Hato
5.0 out of 5 average rating, 19 reviews4 Bedroom Private Pool Paradise in Buenaventura
![](https://a0.muscache.com/im/pictures/hosting/Hosting-U3RheVN1cHBseUxpc3Rpbmc6NTE0NDY5MzM%3D/original/4a1fa9c4-3d4a-4ae9-b68c-06cc1c437404.jpeg?im_w=720)
Condo in Maria Chiquita
5.0 out of 5 average rating, 23 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
![](https://a0.muscache.com/im/pictures/miso/Hosting-961779958830595363/original/131c3235-81b4-46a3-96c7-9f9c20fbde20.jpeg?im_w=720)
Apartment in Panamá
5.0 out of 5 average rating, 23 reviewsTop Floor Condo 6 bedroom with amazing views
![](https://a0.muscache.com/im/pictures/bcfd8c24-8e30-42a4-aaf8-1682df371306.jpg?im_w=720)
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
![](https://a0.muscache.com/im/pictures/hosting/Hosting-36490231/original/6f2dadcf-a993-495d-9e50-2f4f13ce5f7d.jpeg?im_w=720)
Home in Bastimentos
4.8 out of 5 average rating, 99 reviewsSpacious, Over the Water Home with Plunge Pool
![](https://a0.muscache.com/im/pictures/prohost-api/Hosting-39558635/original/a3536aa8-bc70-4051-a146-9c79fc83980b.jpeg?im_w=720)
Apartment in Panama City
4.95 out of 5 average rating, 20 reviews22M Spectacular Penthouse New Design Oceanview
![](https://a0.muscache.com/im/pictures/2eb8e884-9479-439b-9d33-8f0f5f03fd51.jpg?im_w=720)
Villa in Las Escobas del Venado
4.95 out of 5 average rating, 21 reviewsBreathtaking Ocean Villa. Casa de Vida
![](https://a0.muscache.com/im/pictures/miso/Hosting-49498447/original/42fcc8c0-70e9-4c38-b586-86369813e75a.png?im_w=720)
Apartment in María Chiquita
4.94 out of 5 average rating, 67 reviewsPlaya Escondida Resort & Marina
Destinations to explore
- Private suite rentals Panama
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